This mechanism of cell polarization and migration is absent in cells expressing E- or R-cadherin. We show that this mechanical regulation is mediated by the P-cadherin/β-PIX/Cdc42 axis P-cadherin specifically activates Cdc42 through β-PIX, which is specifically recruited at cell–cell contacts upon CCM. Here, using integrated cell biology and biophysical approaches, we determined that P-cadherin specifically induces polarization and CCM through an increase in the strength and anisotropy of mechanical forces. Increased P-cadherin expression levels are correlated with tumor aggressiveness in carcinoma and aggressive sarcoma however, how P-cadherin promotes tumor malignancy remains unknown. ![]() Collective cell migration (CCM) is essential for organism development, wound healing, and metastatic transition, the primary cause of cancer-related death, and it involves cell–cell adhesion molecules of the cadherin family.
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